Nuclear Matrix Protein Matrin3 regulates alternative splicing and forms overlapping regulators networks with PTB
نویسندگان
چکیده
As you will see from the reports, all referees express interest in the findings reported in your manuscript. However, they also do raise a number of specific criticisms that you will have to address before they can support publication of the manuscript. While some of them relate mainly to data presentation, you will also need to include further experimental data to conclusively support the role for Matrin3 in splicing.
منابع مشابه
Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB
Matrin3 is an RNA- and DNA-binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA metabolism has yet been clearly demonstrated. We identified Matrin3 by its interaction with the second RRM domain of the splicing regulator PTB. Using a combination of RNAi kn...
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